At a glance
| Mark on U-100, 1 mL | Volume | at 4.17 mg/mL Zepbound 10 mg multi-dose vial | at 5 mg/mL Zepbound 2.5 mg single-dose vial | at 8.33 mg/mL Zepbound 20 mg multi-dose vial | at 10 mg/mL Zepbound 5 mg single-dose vial | at 12.5 mg/mL Zepbound 30 mg multi-dose vial | at 16.7 mg/mL Zepbound 40 mg multi-dose vial | at 20 mg/mL Zepbound 10 mg single-dose vial | at 25 mg/mL Zepbound 12.5 mg single-dose vial and 60 mg multi-dose vial |
|---|---|---|---|---|---|---|---|---|---|
| 10 units | 0.1 mL | 0.417 mg | 0.5 mg | 0.833 mg | 1 mg | 1.25 mg | 1.67 mg | 2 mg | 2.5 mg |
| 20 units | 0.2 mL | 0.834 mg | 1 mg | 1.67 mg | 2 mg | 2.5 mg | 3.34 mg | 4 mg | 5 mg |
| 25 units | 0.25 mL | 1.04 mg | 1.25 mg | 2.08 mg | 2.5 mg | 3.13 mg | 4.17 mg | 5 mg | 6.25 mg |
| 30 units | 0.3 mL | 1.25 mg | 1.5 mg | 2.5 mg | 3 mg | 3.75 mg | 5.01 mg | 6 mg | 7.5 mg |
| 40 units | 0.4 mL | 1.67 mg | 2 mg | 3.33 mg | 4 mg | 5 mg | 6.68 mg | 8 mg | 10 mg |
| 50 units | 0.5 mL | 2.08 mg | 2.5 mg | 4.17 mg | 5 mg | 6.25 mg | 8.35 mg | 10 mg | 12.5 mg |
| 60 units | 0.6 mL | 2.5 mg | 3 mg | 5 mg | 6 mg | 7.5 mg | 10.02 mg | 12 mg | 15 mg |
Arithmetic at the concentrations shown. The concentration on your own label is the one that counts; enter it in the calculator.
Why the milligrams depend on the vial
25 units is 0.25 mL, half of a Zepbound single-dose vial's 0.5 mL. That is the one thing to notice about this number: no Zepbound label describes it. Half a single-dose vial is 1.25 mg from the 2.5 mg vial, 2.5 mg from the 5 mg vial, 3.75 mg from the 7.5 mg vial, and so on; the table has the full set. From a multi-dose vial, 0.25 mL is a little under half of the labelled 0.6 mL withdrawal. If your instruction is 25 units and your vial is Zepbound, the pharmacy is describing something the manufacturer's label does not, which is a reason to confirm it with them rather than a reason to stop. If your vial is compounded, 25 units is simply 0.25 mL of whatever concentration is on your label.
The mistake to watch for. Splitting a single-dose vial raises two questions the arithmetic cannot answer: whether the remainder keeps, and for how long. The Zepbound label describes each single-dose vial as one dose. Ask before you plan a second draw from it.