The match, and the ways it breaks
A U-100 syringe is marked so that one mark holds one unit of U-100 insulin. That is the whole design: 100 units per millilitre in the vial, 100 marks per millilitre on the barrel, so 10 units is the 10 mark and nobody needs a calculator. The three things on this page all break that match. Veterinary insulin is U-40 and needs a U-40 syringe. Humulin R U-500 is five times as strong and needs its own syringe, and its label says not to convert. And when an insulin syringe is used for a medication that is not insulin, the marks go back to being plain volume.
Check the official label
Every number this page uses was read from these documents on 2026-09-04. The label is the authority; if it disagrees with this page, the label wins.
What the labels say
The wrong U
The wrong U on the syringe. U-40 and U-100 syringes are the same size and shape. U-100 insulin drawn to the 10 mark on a U-40 syringe is 25 units, two and a half times the dose. U-40 insulin drawn to the 10 mark on a U-100 syringe is 4 units. The U number is printed on the box and on the barrel; read both, every time, because the two boxes can sit side by side in the same drawer.
The calculator will not let a U-40 preset be paired with a U-100 syringe or the reverse. If it refuses your combination, that is the check working. The question for the pharmacy, if the boxes do not match: "This insulin is U-40 and these syringes are U-100. Which one is wrong?"
Reading the three sizes
All U-100 syringes share one scale. They differ in how far it goes and how finely it is marked, which is why a small dose is easier to read on a small syringe. Pick a size in the calculator and the drawing changes to match.
| Syringe | Reads | Marks | Where 25 units sits |
|---|---|---|---|
| 1 mL | 0 to 100 | Every 2; numbers every 10 | Halfway between the 24 and 26 ticks |
| 0.5 mL | 0 to 50 | Every 1; numbers every 5 | On the 25 |
| 0.3 mL | 0 to 30 | Every half unit on many brands | On the 25 |
A half-unit dose can only be read on a syringe with half-unit marks. The calculator rounds to the smallest mark on the syringe you chose and tells you when it has.
Worked answers
Two more questions
I use an insulin syringe for a medication that is not insulin. Do the units still apply?
The marks still measure volume, a hundredth of a millilitre each, but they no longer equal your dose. "10 units" does not identify a tirzepatide dose without the vial concentration; 0.1 mL of a stated concentration does. Convert through the concentration on your vial with the main calculator.
My vet prescribed units for my pet. Which syringe?
The one the insulin label names. Vetsulin and ProZinc are U-40 and require U-40 syringes. Some vets prescribe U-100 human insulin for animals, and that needs U-100 syringes. The box of syringes should carry the same U as the box of insulin.